Analgesic effect of morphine-6-glucuronide(M-6-G) for postoperative pain.
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چکیده
منابع مشابه
Morphine-6-glucuronide: morphine's successor for postoperative pain relief?
In searching for an analgesic with fewer side effects than morphine, examination of morphine's active metabolite, morphine-6-glucuronide (M6G), suggests that M6G is possibly such a drug. In contrast to morphine, M6G is not metabolized but excreted via the kidneys and exhibits enterohepatic cycling, as it is a substrate for multidrug resistance transporter proteins in the liver and intestines. M...
متن کاملRelative contribution of morphine and morphine-6-glucuronide to the analgesic effect after morphine administration.
Editor—We thank Dahan and Lotsch for their interest in our review and their valuable comments to the discussion about the role of morphine-6glucuronide (M6G), for the analgesic effect after morphine administration. Because morphine is used worldwide as the potent standard analgesic drug, with the formation of an even more potent metaboliteM6G, it is important to elucidate the relative contribut...
متن کاملThe Influence of Genotype Polymorphism on Morphine Analgesic Effect for Postoperative Pain in Children.
BACKGROUND Although opioids are the most commonly used medications to control postoperative pain in children, the analgesic effects could have a large inter-individual variability according to genotypes. The aim of this study was to investigate the association between single nucleotide polymorphisms and the analgesic effect of morphine for postoperative pain in children. METHODS A prospective...
متن کاملRandomized, double-blind study of the analgesic efficacy of morphine-6-glucuronide versus morphine sulfate for postoperative pain in major surgery.
BACKGROUND Morphine-6-glucuronide (M6G) has promising preclinical characteristics and encouraging pharmacokinetic features for acute nociceptive pain. Early studies have produced a good safety profile when compared to morphine sulfate, although in surrogate pain models studies, a mixed picture emerged. A study to evaluate the efficacy and safety profile in a clinical setting was designed. MET...
متن کاملThe analgesic effect of morphine on postoperative pain in diabetic patients.
BACKGROUND Many clinical and experimental studies have suggested that diabetes or hyperglycemia alter opioid responsiveness. However, little information is available on the effects of diabetes mellitus on opioid requirements in the postoperative period. METHODS Sixty-four patients scheduled for elective, total abdominal hysterectomy were included into this prospective study to evaluate the ef...
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ژورنال
عنوان ژورنال: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
سال: 1991
ISSN: 1882-8272,0388-1601
DOI: 10.3999/jscpt.22.281